Applications

AATI has developed numerous nucleic acid analysis solutions to improve and streamline RNA or DNA based applications, from PCR to CRISPR/Cas9 genome editing.

AATI Scientists looking at data

Applications

Nucleic acids are an essential component of life on earth, and as such, research on, and involving, nucleic acids has blossomed over the past century and a half. Applications including: NGS, molecular cloning, PCR, and CRISPR/Cas9 have become commonplace in laboratories around the world.

CRISPR/Cas9

CRISPR gene editing has swept the life sciences by storm. Use the power of CE to streamline CRISPR workflows with reliable reagent QC and a simple and accurate screening process while simultaneously elucidating the zygosity of positive clones.

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NGS

NGS library QC is essential to the generation of successful sequencing results. Several solutions have been developed to deal with the QC challenges of various types of NGS libraries, from short-read to long-read sequencing platforms, ChIP-seq, RNA-seq, and beyond.

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Genomic DNA

An accurate understanding of genomic DNA quality, quantity, and size is important for numerous methodologies including evaluating isolation success and NGS. Methods of evaluating the quantity, quality, and size of gDNA exist, though many are unable to reliably resolve challenges associated with genomic DNA analysis.

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PCR Fragments

Determination of amplicon size and concentration is a crucial aspect in post-reaction analysis of PCR. Traditional methods of PCR fragment analysis lack the sensitivity and resolution demanded by many applications.

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RNA

Active in myriad biological processes, RNA is the target of many applications, from microarrays to NGS. With diverse types of RNA, small RNA, mRNA, rRNA, and more, unique analytic challenges are posed. Several solutions for the quantification, qualification, and sizing of RNA samples have been developed, though many do not fully address the analytic challenges.

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cfDNA

Cell-free DNA (cfDNA) is of increasing interest to clinicians and researchers alike as a promising biomarker for various disease states. cfDNA requires rigorous assessment of quality prior to use in NGS workflows to ensure successful sequencing results.

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TILLiNG

Commonly employed in plant genetics, TILLiNG (Targeting Induced Local Lesions in Genomes) is a reverse genetics approach used to discover small and point mutations, such as SNPs. Detection of TILLiNG induced mutations depend on heteroduplex assays.

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Oligonucleotide Purity

Determination of oligonucleotide purity is critical for both manufacturers and end-users to ensure quality downstream results. Couple parallel capillary electrophoresis with UV absorption for the confident assessment of ssDNA or ssRNA purity without the use of intercalating dyes or fluorescent probes.

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