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CRISPR

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  • AATI’s Mutation Screening Method for CRISPR Workflows Featured in GEN

    Published: Tuesday, November 28th, 2017
    Tags: CRISPR, Fragment Analyzer

    Integration of an accurate and efficient mutation screening method into CRISPR/Cas genome editing workflows saves researchers time and money by eliminating unnecessary sequencing.

    Genetic Engineering & Biotechnology News recently published a tutorial detailing our solution for CRISPR mutation screening and zygosity determination. Starting with the AccuCleave T7CE Kit, cleavage products are separated using the CRISPR Gel Discovery Kit on the Fragment Analyzer, followed by analysis using a custom plugin for PROSize Data Analysis Software. For more information, read the tutorial here.

  • AATI Featured in CRISPR Commentary

    Published: Tuesday, October 3rd, 2017
    Tags: CRISPR

    AATI’s own Steve Siembieda, Vice President of Commercialization, recently penned a commentary in DDNews on two primary issues in CRISPR genome editing: (1) low specificity and (2) low efficiency.  Put simply, CRISPR technology produces too many off-target mutations and does not have the success rate necessary for adoption into sensitive applications, notably the treatment of genetic illnesses.  The article went on to discuss potential remedies for low specificity and low efficiency in CRISPR workflows and the associated QC and mutation screening challenges.  The Fragment Analyzer supports these remedies and fulfills the QC and screening needs of CRISPR pipelines, accurately assessing the suitability of reagents and identifying and characterizing positive lines.

  • AATI Publishes CRISPR Mutation Screening Protocol

    Published: Thursday, June 22nd, 2017
    Tags: CRISPR, Publications

    Biotechniques recently published an article by Advanced Analytical Technologies, Inc. scientists detailing a streamlined and effective mutation screening protocol for CRISPR/Cas9 workflows. Using T7 Endonuclease I, the optimized heteroduplex assay takes full advantage of the resolution and sensitivity of the Fragment Analyzer.

  • Advanced Analytical Technologies, Inc. (AATI) is Part of Rewriting CRISPR Workflow

    Published: Wednesday, September 21st, 2016
    Tags: CRISPR, Fragment Analyzer

    Large scale CRISPR workflows require efficient and accurate screening for successful editing events. Dr. Kyle Luttgeharm, Application Scientist at AATI, details the use of heteroduplex cleavage assays with the Fragment AnalyzerTM Automated CE System as a high throughput screening protocol in a recent gene therapy feature in GEN.

  • AATI presented at Genome Engineering: The CRISPR-Cas Revolution

    Published: Wednesday, August 17th, 2016
    Tags: CRISPR

    AATI was in attendance at the Genome Engineering: CRISPR-Cas Revolution conference at Cold Spring Harbor Laboratory from August 17 – 20, 2016. Organized by leaders in the field, hot topics at the conference included CRISPR biology, gene drives, genome editing and technology development.

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