Advanced Analytical

Advanced Analytical Technologies, Inc. develops workflow solutions for nucleic acid analysis.

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AATI develops and manufactures capillary electrophoresis based solutions for nucleic acid analysis. The instruments employ parallel capillary electrophoresis, with UV absorbance or fluorescence detection, to streamline nucleic acid analysis and alleviate analytic bottlenecks. AATI’s nucleic acid analysis solutions are ideal for any application, from NGS library QC and CRISPR/Cas9 mutation detection to determining oligonucleotide purity and genomic DNA analysis.

Upcoming Events

Jan 13 - 17
PAG 2018
Plant & Animal Genome XXVI Meeting
Town & Country Hotel in San Diego, CA - USA
Jan 24 - 28
Assises de Génétique Humaine et Médicale
The City, The Nantes Conference Center in Nantes - France
Jan 25 - 26
GESB 3rd Edition
Genome Engineering and Synthetic Biology 3rd Edition
Bruges, Belgium

Recent News

AATI’s Mutation Screening Method for CRISPR Workflows Featured in GEN

Integration of an accurate and efficient mutation screening method into CRISPR/Cas genome editing workflows saves researchers time and money by eliminating unnecessary sequencing.

Genetic Engineering & Biotechnology News recently published a tutorial detailing our solution for CRISPR mutation screening and zygosity determination. Starting with the AccuCleave T7CE Kit, cleavage products are separated using the CRISPR Gel Discovery Kit on the Fragment Analyzer, followed by analysis using a custom plugin for PROSize Data Analysis Software. For more information, read the tutorial here.

AATI Featured in CRISPR Commentary

AATI’s own Steve Siembieda, Vice President of Commercialization, recently penned a commentary in DDNews on two primary issues in CRISPR genome editing: (1) low specificity and (2) low efficiency.  Put simply, CRISPR technology produces too many off-target mutations and does not have the success rate necessary for adoption into sensitive applications, notably the treatment of genetic illnesses.  The article went on to discuss potential remedies for low specificity and low efficiency in CRISPR workflows and the associated QC and mutation screening challenges.  The Fragment Analyzer supports these remedies and fulfills the QC and screening needs of CRISPR pipelines, accurately assessing the suitability of reagents and identifying and characterizing positive lines.

AATI and Illumina Partner to Promote Scalable NGS QC Solutions

Advanced Analytical Technologies, Inc (AATI) is excited to partner with Illumina to support collaborations and co-marketing activities involving our Fragment Analyzer™ Automated CE Systems for quality assessment of nucleic acids in Illumina next-generation sequencing (NGS) workflows. Assessing nucleic acid quality is essential for the success of NGS applications. The Fragment Analyzer provides a scalable method, tested by Illumina, for accurate analysis of a broad range of sample types in Illumina NGS library prep workflows, including genomic DNA, RNA, cell-free liquid biopsy, single-cell isolates, and prepared libraries before sequencing. Illumina has published an Application Note that provides an overview o

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