pKa Technical Specifications

Electrical:

• 100 – 200 VAC; 50 – 60 Hz (200 – 230 VAC; 50 – 60 Hz available); 15 Amps
• CE Certified

Physical Dimensions:

• Mass: 88.6 kg (195 lbs)
• Size: H x W x D = 58.4 x 63.5 x 92 cm (23 x 25 x 36.25 in.)
• With top open: H = 99.1 cm (39 in.)
• Fully configured dimensions: H x W x D = 99.1 x 76.2 x 243.8 cm (39 x 30 x 96 in.)

Software:

• Proprietary pKa PRO™ software for system control/data analysis

Data Export Format:

• Microsoft® Excel

Environmental Conditions:

• Indoor use, normal laboratory environment

External Temperature:

• 20° to 23° C (68° to 73.4° F)

Relative Humidity:

• Less than 80% (no condensation)

pKa Measurement Range:

• 1.7 – 11.2

Log P Measurement Range:

• -0.5 to 5.0 (pH 10.0)

Detection Wavelength:

• 214 nm (other wavelengths available; compound chromophore does not have to be in proximity to ionization center)

Detection Sensitivity:

• 5 – 10 μg/ml (ppm) depending upon chromophore; typical working concentration
  50 – 100 μg/ml

Sample Volume Required:

• 50 μl/sample well (min. 20 μl/well); 24 wells per 24 pH analysis; 12 wells per 12 pH analysis

Sample Format:

• Typical DMSO concentration 0.1 – 0.2% (v/v); higher DMSO concentrations tolerated at higher wavelengths

Maximum Sample Throughput:

• 12 compounds/h for 24-point aqueous pKa measurement (pKa PRO™ 96XT)
• 3 compounds/h for 24-point aqueous pKa measurement (pKa PRO™ 24HT)

Sample Purity Requirements:

• Compound of interest should be major species present; impurities and degradants can often be separated

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