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Company History
Advanced Analytical Technologies, Inc. (Advanced Analytical) was founded in 1998 in Ames, IA. This privately-held corporation is comprised of a team of highly-qualified scientists, engineers and support personnel whose specialties include flow cytometry, cell biology, microbiology, analytical chemistry, and optical engineering. The company has developed a rapid microbiology platform to replace the traditional method of growing microbial organisms on agar plates. The traditional method is very time-consuming, less precise, and can take days to get results.
On December 1, 2006 Advanced Analytical completed a merger with CombiSep, Inc., a company founded in December, 1999. CombiSep provides innovative solutions to accelerate pharmaceutical and life sciences research. CombiSep's core technology enables researchers to analyze up to 96 samples in parallel by capillary electrophoresis with UV absorbance detection. Dedicated analyzers with a complete line of reagents are available for performing physicochemical profiling of drug compounds and for performing DNA/RNA oligonucleotide purity analysis. Additional application areas include antibody/protein analysis and chiral separations.
Advanced Analytical Milestones
AATI dates (orange); CombiSep dates (blue)
- 1998 Advanced Analytical is Founded
- Company founded with a focus on adapting flow cytometer technology to the detection of low levels of microbial cells.
- 1999 First Advanced Analytical Unit is Shipped
- Advanced Analytical ships their first commercial unit.
- December, 1999 CombiSep is Founded
- Company is founded based upon technology developed by Professor Edward Yeung, Ph.D. at Iowa State University. In the following months CombiSep secures exclusive, world-wide rights to the core technology and begins operations.
- February, 2001 First Commercial CombiSep System Shipped
- CombiSep ships their first commercial unit, the MCE 2000, to Proctor and Gamble.
- May, 2001 Advanced Analytical Signs a Cooperative Research and Development Agreement (CRADA) with the U.S. EPA
- The collaboration will focus on developing a rapid method of detection and enumeration of Enterococcus spp. bacteria as indicator organisms of fecal contamination in the water along U.S. beach fronts.
- May, 2002 Advanced Analytical Awarded a Phase I SBIR Project from the USDA
- This Phase I SBIR project is entitled "Rapid Detection of E. coli O157:H7, Salmonella spp. and Listeria spp."
- March, 2003 Advanced Analytical Receives the First Order from Aberdeen Proving Grounds
- Advanced Analytical announces it has received an order from the U.S. Army Soldier and Biological Chemical Command (SBCCOM) for purchase of an RBD 3000 Rapid Bacterial Detection System. This is the first of three units eventually purchased by SBCCOM.
- May, 2003 CombiSep Begins Shipment of Its Second Generation System, the cePRO 9600™
- The cePRO 9600™ system provides significant enhancements in automation, software and performance.
- March, 2005 CombiSep Receives the 2005 Product Differentiation Award from Frost & Sullivan
- Frost & Sullivan presented the 2005 Award for Product Differentiation Leadership in the U.S. absorption, distribution, metabolism, and excretion/toxicology (ADME/Tox) market to CombiSep, Inc. for the cePRO 9600™ system.
- August, 2005 CombiSep Introduces the pKa Analyzer PRO™ System
- The pKa Analyzer PRO™ system measures the acid dissociation constants (pKa values) of water soluble and insoluble compounds, and is the first in a new series of focused system solutions for the pharmaceutical and biotech markets.
- April, 2006 Advanced Analytical Signs a Cooperative Research and Development Agreement (CRADA) with the U.S. Army
- This CRADA with the U.S. Army Edgewood Chemical Biological Center at the Aberdeen Proving Ground is focused on the potential application of the company technology to rapidly detect bioterrorism agents.
- September, 2006 CombiSep Introduces the Oligo PRO™ System
- The second in a series of dedicated analyzers, the Oligo PRO™ system provides a rapid solution for performing DNA and RNA oligonucleotide purity analysis.
- December, 2006 CombiSep Merges with Advanced Analytical
- On December 1, 2006 Advanced Analytical and CombiSep completed a merger. The combination of these two companies provides for a much broader product offering, expands the scientific, technical, and management expertise plus raises the market awareness with more resources through complementary sales channels.
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